<table > <tr> <th>中文名称</th> <td>磷酸化蛋白激酶B抗体</td></tr> <tr> <th>英文名称</th> <td>Rabbit Anti-phospho-AKT1 (Ser129) antibody </td></tr> <tr> <th>别名</th> <td>AKT1 (phospho Ser129); p-AKT1 (phospho S129); AKT 1; AKT; AKT1; AKT-1; AKT1_HUMAN; C AKT; cAKT; MGC9965; MGC99656; Oncogene AKT1; PKB; PKB alpha; PKB-ALPHA; PRKBA; Protein Kinase B Alpha; Protein kinase B; Proto-oncogene c-Akt; RAC Alpha; RAC alpha serine/threonine protein kinase; RAC; RAC PK Alpha; Rac protein kinase alpha; RAC Serine/Threonine Protein Kinase; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; v akt murine thymoma viral oncogene homolog 1; vAKT Murine Thymoma Viral Oncogene Homolog 1.  </td></tr> <tr> <th>抗体来源</th> <td>Rabbit</td></tr> <tr> <th>克隆类型</th> <td>Polyclonal</td></tr> <tr> <th>交叉反应</th> <td>Human,(predicted: Mouse,Rat,Chicken,Dog,Horse,)</td></tr> <tr> <th>亚型</th> <td>IgG</td></tr> <tr> <th>免疫原</th> <td>KLH conjugated Synthesised phosphopeptide derived from human Akt1 around the phosphorylation site of Ser129:DN(p-S)GA</td></tr> <tr> <th>细胞定位</th> <td>细胞核细胞浆细胞膜</td></tr> <tr> <th>纯化方法</th> <td>affinity purified by Protein A</td></tr> <tr> <th>性状</th> <td>Liquid</td></tr> <tr> <th>储存液</th> <td>0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.</td></tr> <tr> <th>浓度</th> <td>1mg/ml</td></tr> <tr> <th>产品应用</th> <td>WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （石蜡切片需做抗原修复） <br /> not yet tested in other applications.<br> optimal dilutions/concentrations should be determined by the end user.</td></tr> <tr> <th>分子量</th> <td>56kDa</td></tr> <tr> <th>产品介绍</th> <td>This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. These highly similar AKT proteins all have an N-terminal pleckstrin homology domain, a serine/threonine-specific kinase domain and a C-terminal regulatory domain. These proteins are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K forms a key component of many signalling pathways that involve the binding of membrane-bound ligands such as receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase. These AKT proteins therefore regulate a wide variety of cellular functions including cell proliferation, survival, metabolism, and angiogenesis in both normal and malignant cells. AKT proteins are recruited to the cell membrane by phosphatidylinositol 3,4,5-trisphosphate (PIP3) after phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) by PI3K. Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. Phosphorylation of additional residues also occurs, for example, in response to insulin growth factor-1 and epidermal growth factor. Protein phosphatases act as negative regulators of AKT proteins by dephosphorylating AKT or PIP3. The PI3K/AKT signalling pathway is crucial for tumor cell survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating AKT1 which then phosphorylates and inactivates components of the apoptotic machinery. AKT proteins also participate in the mammalian target of rapamycin (mTOR) signalling pathway which controls the assembly of the eukaryotic translation initiation factor 4F (eIF4E) complex and this pathway, in addition to responding to extracellular signals from growth factors and cytokines, is disregulated in many cancers. Mutations in this gene are associated with multiple types of cancer and excessive tissue growth including Proteus syndrome and Cowden syndrome 6, and breast, colorectal, and ovarian cancers. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2020]</td></tr> <tr> <th>选择标记产品</th> <td><a href=/product/IAC327488-100ul.html>AP标记</a><br><a href=/product/IAC327489-100ul.html>APC标记</a><br><a href=/product/IAC327490-100ul.html>FITC标记</a><br><a href=/product/IAC113129-100ul.html>CY3标记</a><br><a href=/product/IAC149259-100ul.html>CY5标记</a><br></td></tr> </table>