IAA00004-200ul
200ul
| 产品编号 | 规格 | 货期 | 销售价 | 折扣价 | 数量 | 操作 |
|---|---|---|---|---|---|---|
| IAA00004-100ul | 100ul |
10天
|
2256.00 | 2256.00 |
 
|
|
| IAA00004-200ul | 200ul |
10天
|
3480.00 | 3480.00 |
|
|
| IAA00004-50ul | 50ul |
10天
|
1317.60 | 1317.60 |
|
| 中文名称 | 活化半胱胺酸蛋白酶蛋白-3抗体 |
|---|---|
| 英文名称 | Rabbit Anti-Caspase-3 antibody |
| 别名 | Caspase-3 subunit p17; cleaved Caspase 3; cleaved Caspase-3; APOPAIN; CASP3; Caspase 3 apoptosis related cysteine protease; Caspase3; CPP32; CPP32B; Cysteine protease CPP32; Human cysteine protease CPP32 isoform alpha mRNA complete cds; PARP cleavage protease; SCA 1; SCA1; SREBP cleavage activity 1; Yama; CASP3_HUMAN; Caspase-3; CASP-3; Apopain; Protein Yama; SREBP cleavage activity 1; SCA-1. |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human,Mouse,Rat,Rabbit,(predicted: Dog,Pig,Cow,Horse,Sheep,) |
| 亚型 | IgG |
| 免疫原 | KLH conjugated synthetic peptide derived from human caspase-3 p17 subunit:1-100/277 |
| 细胞定位 | 细胞浆 |
| 纯化方法 | affinity purified by Protein A |
| 性状 | Liquid |
| 储存液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 产品应用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分子量 | 28kDa |
| 研究领域 | 肿瘤, 细胞生物, 神经生物学, 信号转导, 细胞凋亡, Alzheimer's Disease, |
| 产品介绍 | The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. |
| 选择标记产品 | AP标记 APC标记 FITC标记 CY3标记 CY5标记 Biotin 标记 PE-CY3标记 PE-CY5标记 Alexa Fluor 350 标记 Alexa Fluor 488 标记 PE标记 HRP标记 Gold标记 CY5.5标记 CY7标记 RBITC标记 PE-CY5.5标记 PE-CY7标记 Alexa Fluor 555 标记 Alexa Fluor 594 标记 Alexa Fluor 647 标记 |
