HPS2372-95
350228-37-4
默认>95%HPLC,若需其他规格请洽询
产品编号 | 规格 | 货期 | 销售价 | 折扣价 | 数量 | 操作 |
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HPS2372-95 | 默认>95%HPLC,若需其他规格请洽询 |
25天
|
敬请询价 | 敬请询价 |
|
名字 | (Asn⁶⁷⁰,Sta⁶⁷¹,Val⁶⁷²)-Amyloid β/A4 Protein Precursor₇₇₀ (662-675) ammonium salt |
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序列(三字母) | H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe-OH ammonium salt |
序列(单字母) | KTEEISEVN-Sta-VAEF |
CAS# | 350228-37-4 |
分子式 | C₇₃H₁₁₈N₁₆O₂₇ |
分子量 | 1651.83 |
纯度 | 默认>95%HPLC,若需其他规格请洽询 |
合成方法 | Synthetic |
储存条件 | -20 ± 5 °C |
应用 | Alzheimer´s Disease |
描述 | Amyloid precursor protein (APP) β-secretase from human brain cleaves full-length APP at the amino terminus of the amyloid β-protein (Aβ) sequence, thus leading to the generation and extracellular release of β-cleaved soluble APP and a corresponding cell-associated carboxy-terminal fragment. The subsequent cleavage of the C-terminal fragment by γ-secretase(s) leads to the formation of Aβ. This new peptide represents a potent substrate analog inhibitor of APP β-secretase with IC₅₀ = 30 nM. |