HPS2245-95
148439-49-0
默认>95%HPLC，若需其他规格请洽询
| 产品编号 | 规格 | 货期 | 销售价 | 折扣价 | 数量 | 操作 |
|---|---|---|---|---|---|---|
| HPS2245-95 | 默认>95%HPLC，若需其他规格请洽询 |
25天
|
敬请询价 | 敬请询价 |
 
|
| 名字 | Prion Protein (106-126) (human) trifluoroacetate salt |
|---|---|
| 序列(三字母) | H-Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly-OH trifluoroacetate salt |
| 序列(单字母) | KTNMKHMAGAAAAGAVVGGLG |
| CAS# | 148439-49-0 |
| 分子式 | C₈₀H₁₃₈N₂₆O₂₄S₂ |
| 分子量 | 1912.27 |
| 纯度 | 默认>95%HPLC，若需其他规格请洽询 |
| 合成方法 | Synthetic |
| 储存条件 | -20 ± 5 °C |
| 应用 | Apoptosis & Necrosis |
| 描述 | An altered form of the large cellular prion protein accumulates in the CNS of patients with neurodegenerative disorders, and its protease-resistant core aggregates extracellularly into amyloid fibrils. This process is accompanied by nerve cell loss. The 21-peptide KTNMKHMAGAAAAGAVVGGLG is used as a model to investigate neurodegeneration in prion diseases. Prion Protein (106-126) forms fibrils in vitro and causes apoptotic cell death in neuron culture. Its neurotoxicity depends on the presence of microglia and is induced by microglia. It could be demonstrated that KTNMKHMAGAAAAGAVVGGLG is able to bind to DNA, a circumstance which led to the assumption that the integral protein could also bind to DNA under appropriate solution conditions. |
