HPS0366-95
154947-66-7
默认>95%HPLC，若需其他规格请洽询
| 产品编号 | 规格 | 货期 | 销售价 | 折扣价 | 数量 | 操作 |
|---|---|---|---|---|---|---|
| HPS0366-95 | 默认>95%HPLC，若需其他规格请洽询 |
25天
|
敬请询价 | 敬请询价 |
 
|
| 名字 | LL-37 |
|---|---|
| 序列(三字母) | H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH |
| 序列(单字母) | LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES |
| CAS# | 154947-66-7 |
| 分子式 | C₂₀₅H₃₄₀N₆₀O₅₃ |
| 分子量 | 4493.33 |
| 纯度 | 默认>95%HPLC，若需其他规格请洽询 |
| 合成方法 | 固相合成 |
| 储存条件 | 请置于-20 ± 5 °C 且避光、干燥的环境中 |
| 应用 | Angiogenesis|Antimicrobial & Antiviral Peptides|Cancer Research|Inflammation Research |
| 描述 | LL-37 is an antimicrobial peptide with angiogenic activity. It corresponds to the C-terminal sequence (134-170) of the human cathelicidin antimicrobial protein hCAP18/LL-37 and is extracellularly released from hCAP18/LL-37 by proteolytic processing. hCAP18/LL-37 is an effector of the innate immune system and is expressed in leukocytes and epithelial cells where it is upregulated in association with inflammation and injury. An overexpression of hCAP18/LL-37 in a series of breast carcinomas could be demonstrated. LL-37 has been suggested to stimulate epithelial cell proliferation partially through formyl peptide receptor-like 1 (FPRL1) since blocking the receptor with pertussis toxin decreased the proliferative effect of LL-37 by approximately 50 %. |
